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Hello, everyone, and welcome to another busy day. And a cold one, too. We have momentarily left the Pharmalot campus for the STAT nerve center, where rather frigid temperatures are descending. Of course, the secret to keeping warm is to quaff a few cups of stimulation. So why not join us? After all, a prescription is not required. Meanwhile, here are your tidbits. Hope you conquer the world today and, of course, do keep in touch. We enjoy your notes …

Last-ditch talks are underway between Ireland’s Health Service Executive and Vertex Pharmaceuticals over the price of the Orkambi cystic fibrosis treatment, the Irish Times reports. The move follows pressure by patients, but health officials are not optimistic about reaching an agreement about an acceptable cost. Minister for Health Simon Harris declared he would not be “bullied or extorted” by a drug company seeking an excessive payment.

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