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The number of complaints filed in the U.K. against drug makers over marketing infractions jumped substantially last year, according to the latest figures compiled by an industry-sponsored watchdog.

Overall, 76 complaints were registered in 2016, a 40 percent rise from the 54 that were filed in the previous year and, notably, there was a 30 percent jump in the most serious type of complaint — violations that discredit the entire industry. Many of the largest drug makers made this list. In addition, the number of individual allegations contained in each complaint reviewed was 420 last year, up from 198 in 2015.

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