For the third time in six months, Pfizer (PFE) is having difficulty manufacturing certain prefilled syringes of opioid painkillers — and the ongoing supply problems are upsetting hospitals around the country.

The string of difficulties are all occurring at a specific plant that has recently encountered manufacturing issues, although the latest snag with the Carpuject and iSecure syringes is being traced to a component made by a supplier, according to a Jan. 31 letter that Pfizer sent to its customers.

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