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And so, another working week will soon draw to a close. Not a moment too soon, yes? This is, you may recall, our treasured signal to daydream about weekend plans. Our agenda has a few hopeful highlights. We plan to hang with our short person, catch up on our reading, watch a moving picture, and visit the Pharmalot ancestors. We will have more time to indulge, since this will be a long weekend to observe dead Presidents, which means we will return to you on Tuesday. Meanwhile, what will you be doing? This is a fine time to ready your taxes. Remember, Uncle Sam wants you … to pay up. Maybe this is an opportunity to connect with someone special or take stock of life. Or you could contact your congressional representative and urge them to send thoughts and prayers for the latest mass shooting victims. Well, whatever you do, be safe. Enjoy, and see you soon …

The Food and Drug Administration wants to let drug makers test Alzheimer’s disease treatments on patients years before the disease shows outward signs, and could approve the therapies based on subtle biological signals rather than proof they alleviate symptoms, Bloomberg News notes. The agency loosened the standard for drug makers to move ahead in a draft guidance that cuts a line from a 2013 policy calling for “widespread evidence-based agreement in the research community” about the right biological signal.

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