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In the latest challenge to a drug maker over the pricing of its medicines, a cost-effectiveness watchdog has determined that all three cystic fibrosis drugs sold by Vertex Pharmaceuticals (VRTX) are overpriced — and by considerable amounts.

How much? Vertex would have to lower its prices from 71 percent to 77 percent in order to align costs with the benefits, according to a review by the Institute for Clinical and Economic Review.

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