A long-running effort to provide coverage in the U.K. for a cystic fibrosis drug has reached an impasse as health officials maintain the price offered by Vertex (VRTX) Pharmaceuticals (VRTX) is “unsupportable,” while the company called their position “outrageous” and “unconscionable.”

At issue is the Orkambi treatment, which was determined not to be cost effective by the U.K.’s National Institute for Health and Care Excellence. As a result, the National Health Service in England is refusing to provide coverage unless Vertex lowers the price. About 10,400 people suffer from cystic fibrosis in the U.K., and more than 116,000 people have signed an online petition demanding NHS coverage.

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