Although progression-free survival is increasingly used in clinical trials to validate cancer medicines, a new study indicates this approach is not necessarily improving patient quality of life.

An analysis of 52 articles reporting on 38 randomized clinical trials involving nearly 14,000 patients — who were suffering from 12 different forms of cancer — found no significant association between health-related quality of life and survival when the disease was not worsening. The researchers reviewed trials that were published from 2000 to 2016.

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