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Despite strict rules requiring clinical trial reporting, about half of the clinical trials in the U.K. are not reported, clinical trial registration is not yet universal, and reported outcomes do not always match original study proposals, according to a new parliamentary report.

As a result, there is a threat to research integrity. The lack of published results means that information on the effectiveness of new drugs cannot be used. And the lack of transparency presents risks to human health, contributes to research wastage, and means that clinical decisions are made without access to all the available evidence, according to the Science and Technology Committee, which issued the report.

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