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And so, another working week will soon draw to a close. Not a moment too soon, yes? This is, you may recall, our treasured signal to daydream about weekend plans. In fact, we have a lot of daydreaming to do, since we will be off for several days. Our agenda is rather modest, but hopefully satisfying. We plan to spend time with Mrs. Pharmalot and some Pharmalittles, catch up on our endless reading list, sponsor a listening party or two, observe some ancient rituals, and check in on a few long-lost family and friends. And what about you? This is a splendid opportunity to reacquaint yourself with people who matter, indulge your favorite pastimes, or simply plan the rest of your life. Well, whatever you do, have a grand time. But be safe. Enjoy, and see you next year.

The National Academies of Sciences, Engineering, and Medicine outlined a framework for prescribers and others to develop their own plans for acute pain, without offering any direct recommendations itself, STAT explains. The report says any group drafting prescribing guidelines should consider a host of factors: evidence, or lack thereof, for using opioids versus alternatives for a condition or procedure; downstream effects of any prescription, such as refill requests or unused pills; and potential implications on pain relief, quality of life, and harm.

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