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The results of more than one-fifth of clinical trials that were conducted in Belgium have not been reported to a European database more than a year after the studies were completed, according to a new analysis that adds to the evidence of problems with clinical trial transparency.

More than a dozen of the largest trial sponsors based in the country have registered 1,098 studies of investigative medicines on the European Union Clinical Trial Register. Of those, 292 trials were completed more than a year ago, but results were missing for 64, or 22%. The actual number of missing results may be higher, though, due to weak data management by trial sponsors and regulators.

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