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As Americans grapple with prescription drug costs, two new companies are being launched in hopes of transforming the opaque pharmaceutical supply chain that bedevils employers.

The Mark Cuban Cost Plus Drug Company and the Purchaser Business Group on Health, a coalition of 40 large private and public employers, are both creating pharmacy benefits managers. Known as PBMs, these controversial, behind-the-scenes entities play a crucial role in establishing prescription drug prices across the U.S.

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