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Biogen (BIIB) is preparing for its largest-ever layoff in which more than 1,000 employees are expected to lose their jobs, STAT reports. Details are still being ironed out, including sign-off from the Biogen board of directors, but the restructuring plan would cut expenses in the range of $500 million to $750 million. People close to Biogen told STAT the company’s top scientist, Al Sandrock, was pushed out, and Alphonse Galdes, a company lifer who oversees global manufacturing and who has been a stabilizing force in its managerial ranks for nearly three decades, is also leaving the company. The moves come after the polarizing approval and disastrous commercial rollout of the Aduhelm drug for Alzheimer’s.

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