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Three of the largest pharmaceutical wholesalers and a major drugmaker have reached a $590 million deal to settle lawsuits filed by hundreds of Native American tribes accusing the companies of fomenting the opioid crisis, which has claimed half a million lives over nearly two decades.

The agreement was disclosed in a court filing made public Tuesday.

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As part of the settlement, the wholesalers — McKesson (MCK), AmerisourceBergen (ABC), and Cardinal Health (CAH) — will pay nearly $440 million over seven years, while the Janssen unit at Johnson & Johnson (JNJ) agreed to $150 million over two years. This does not include a $75 million settlement previously agreed to by the Cherokee Nation and the three distributors.

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