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Drug safety advisories issued by regulators regularly led to reduced prescribing by physicians by an average of nearly 6%, lowering the potential for patients to encounter potentially harmful or fatal reactions, a new study finds.

After examining two dozen advisories issued in Canada, Denmark, the U.S., and the U.K. between 2009 and 2015, researchers found that on average, prescribing for the drugs — mainly used in primary care — declined by 5.8%. These advisories did not include specific dosage information. For the four advisories with dosage advice, the average decline was 1.9%, which was not statistically significant or considered conclusive, given the small number.

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