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Amid ongoing turmoil over the cost of prescription medicines, a new analysis finds that brand-name drugmakers increased their wholesale prices by 4.4% in the last quarter of 2021, up slightly from 3.8% a year earlier. But when accounting for inflation, wholesale prices fell by 2.3%.

At the same time, net prices that health plans paid for medicines — after subtracting rebates, discounts, and fees — dropped by 0.7%. But after considering inflation, net prices actually fell 5.4%. In both instances, these were the largest quarterly declines in real terms in 15 years, according to SSR Health, a research firm that tracks the pharmaceutical industry.

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In fact, 92% of publicly traded brand-name drug companies experienced declines in wholesale prices in real terms, with an “unprecedented” 88% of brand-name medicines affected. Meanwhile, the so-called gross-to-net bubble — which measures the gap between gross sales at list prices and net prices after rebates – inched up slightly to 47.5%, continuing an upward trend over the past six years.

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