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On the eve of a trial, the state of Florida has reached a settlement with a major pharmacy chain and two drug manufacturers over their roles in fomenting the opioid crisis that has gripped the United States for more than two decades.

CVS Health will pay $484 million, and Allergan —a unit of AbbVie — agreed to pay $134 million to settle a lawsuit filed by the state. In addition, Teva Pharmaceuticals will pay $195 million, and also provide $84 million worth of its generic version of Narcan, a nasal spray that is used to treat opioid overdoses in emergencies.

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